PROJECT

THE PROBLEM

Organophosphate phosphotriesterases (OPs) are synthetic compounds that constitute the largest class of worldwide-employed pesticides (Paraoxon, Parathion) and some of them are potent chemical warfare agents (CWA) as Sarin and Soman. These compounds are toxic for all vertebrates because they irreversibly inhibit the acetylcholinesterase (AChE), a key enzyme of the nervous system.

 

Pesticides

Farming-HD-440x268

 

It has been estimated that 3,000,000 cases of severe poisoning and 250,000 deaths are caused globally every year by pesticides (World Health Organization, 2014). Humans are exposed to OPs via ingested food and drink and by breathing polluted air (WHO, 2001).

 

 

 

 

Nerve Agents

VX-Nerve-Agent

 

Organophosphates were modified during World War II to create compounds more toxic, better knows as nerve gases (Sarin, Soman,VX) today used during terroristic attacks .

 

 

 

 

 

 

DETOXIZYMES SOLUTION

Our technology is mainly based on the use of PLL (Phosphotriesterase Like- Lactonases) enzymes, deriving from extremophilic microorganisms of Solfatara (Pozzuoli, NA) as biodecontaminant to hydrolyze Organophosphates (OPs) and the innovation lies in their high operative stability that allows to use in vitro evolution techniques to improve the enzymatic functions and meet specific market demands.

 

Competitive advantage

Stability: the thermophilic enzymes can be used in high temperature and in stressful operative conditions such as presence of solvents, detergents, and oxidant substances. In addition stability allows a long preservation of the product. Easy to transport: enzymes are lyophilized so volumetric dimensions are reduced. Green technology: enzymes are proteins, so they are biodegradable and don’t pollute the environment because they don’t require specific disposal systems. Competitive price.